Bovine Spongiform Encephalophathy Essay -- BSE Prion Mad Cow Disease

Bovine Spongiform Encephalophathy Abstract: Bovine spongiform encephalopathy is caused by a prion, which is an infectious agent comprised solely of protein. The prion is a degenerate form of a normal cellular protein found in the brain and in nervous tissue. It targets the normal protein and causes the normal protein to change its shape. When enough of the prion is produced, the cell dies and symptoms of the disease are expressed. Bovine spongiform encephalopathy (BSE), more commonly known as mad cow disease, is an unusual disease in regards to the fact that it is not caused by bacteria, viruses, fungi, or any other organism. Instead the disease is caused by prions, infectious agents simply composed of protein. Prions lack nucleic acid and are composed of an abnormal isoform of a normal cellular protein. What this means is that the prions and the cellular proteins have the same arrangements of the amino acids; however, the prion is folded differently from the cellular protein. "They are much like the toy "Transformers" that intrigued little kids in the 1980s. A sphynx could become a robot; a bug could become a warrior. Nothing was added; nothing subtracted."(Ruth Levy Guyer, Ph.D., 1) The tightly wound alpha helixes (figure 2) of the normal cellular proteins are unfolded and turn into beta sheets (figure 1). (Ruth Levy Guyer, Ph.D., 1) Figure 1 Figure 2 Another feature of the prion is its ability to remain stable in extreme conditions. Because prions do not have any DNA or RNA like other infectious agents, they are very hard to deal with. Prions are extremely resistant to conventional procedures to inactivate them including irradiation, boiling, dry heat, and chemicals such asformalin, betapropiolactone, and alcohols. S... ...is a disease that runs in families and prevents people from sleeping, causes motor and emotional problems, and is eventually a killer. GSS was linked to two mutations in the prion gene in 1989. Prion fragments accumulate in the brain in structures called plaques. In Alzheimer's disease, similar plaques develop, but they are composed of fragments of a different protein. Works Cited â€Å"Prion† Wikipedia. 28 July 2006 . DeArmond, Stephen J., M.D., Ph.D., Safar, Jiri, M.D., Groth, Darlene, A.B., Prusiner, Stanley B., M.D. â€Å"Prions† Office of Health and Safety. 28 July 2006 . Guyer, Ruth Levy, Ph.D. â€Å"Prions: Puzzling Infectious Proteins† National Institutes of Health Office of Science. 28 July 2006 .

The Golden Rule :: social issues

The Golden Rule ‘The Golden Rule and The Greatest Good’ what can they do? It was around 4 pm that Tosin Olumito and I got to the main campus of Ahmadu Bello University Samaru, Zaria after a long journey from Ilorin, Kwara State. Our mission was to process our admission having finished the Interim Joint Matriculation board Examination of which we obtained a very good result. In Ilorin, we had been directed to a friend who was a student in the school to put us through and to offer us accommodation for timeous processing and efficient follow up of the admission but alas! The school joined the 6 months strike called by ASUU. We knew they were on strike, the news we heard was that admission had started and that they would soon called it off to join some of their colleagues who had called their student to resume without a definite announcement by ASUU, which they eventually did after a week that we got to the university. We tried and searched every nook and cranny of the university to locate the friend we were directed to until somebody nimbled us that the stude nt we were looking for had traveled. All hope shattered, we looked at each other amazingly, we were now left to carry our cross and look for a panacea to this menace. We couldn’t go to a hotel neither do we have relatives within the vicinity. Tosin has a relative in Kaduna, which is 45 minutes drive from Zaria. I alluded that she should go to Kaduna to locate her relatives, that I would find a way of harboring myself. She wanted to disagree having thought of the risk, which I would be exposed to. She insisted on knowing where I would be so that she could check the following day to inform me whether I should come also to Kaduna or not . I told her that I would not be able to afford the transport implication which could adversely affect my pocket money because I was left with a token that could last for few days apart from my fare to Ilorin. She was convinced. As luck would have it, I met and told a Hausa student our plague who introduced us to his friend – Suleiman Nuhu Bala, a final year Economics student who was at the time writing his project. Suleiman didn’t hesitate to

Comparison Of Martin Luther King Jr And Malcom X :: Compare Contrast Essays

They were black men who had a dream, but never lived to see it fulfilled. One was a man who spoke out to all humanity, but the world was not yet ready for his peaceful words. "I have a dream, a dream that one day this nation will rise up and live out the true meaning of its creed... that all men are created equal." (Martin Luther King) The other, a man who spoke of a violent revolution, which would bring about radical change for the black race. "Anything you can think of that you want to change right now, the only way you can do it is with a ballot or a bullet. And if you're not ready to get involved with either one of those, you are satisfied with the status quo. That means we'll have to change you." (Malcom X) While Martin Luther King promoted non-violence, civil rights, and the end to racial segregation, a man of the name of Malcom X dreamed of a separate nation. Martin Luther King, Jr. was the conscience of his generation. A Southerner, a black man, he gazed upon the great wall of segregation and saw that the power of love could bring it down. From the pain and exhaustion of his fight to free all people from the bondage of separation and injustice, he wrung his eloquent statement of what America could be. (Ansboro, pg.1) An American clergyman and a Nobel Peace Prize winner, he was one of the principle leaders of the American Civil Rights Movement and a prominent advocate of nonviolent protest. King's challenges to segregation and racial discrimination in the 1950's and 1960's, helped convince many white Americans to support the cause of civil rights in the United States. After his assassination in 1968, King became the symbol of protest in the struggle for racial justice. ("King, Martin Luther, Jr.," pg. 1) In 1964, Malcom X founded an organization called "The Muslim Mosque, Inc. In an interview conducted by A.B. Spellman on March 19, 1964, Malcom speaks of his goals for this organization. "The Muslim Mosque, Inc. will have as its religious base the religion of Islam, which will be designed to propagate the moral reformations necesary to up the level of the so-called Negro community by eliminating the vices and other evils that destroy the moral fiber of the community. But the political philosophy of the Muslim Mosque will be black nationalism, as well as the social and economic philosophies.

Pc tech; consulting repairs, training, networking and upgrading

Executive SummaryPersonal computer Tech will supply computing machine and proficient consulting fixs, preparation, networking and upgrading service to local and little concern every bit good as place Personal computer users. The Company will concentrate on selling, reactivity, quality and making client dealingss. Personal computer Tech was ab initio formed as a exclusive proprietary, but was reconfigured as an Personal computer Technical school in January 2003 PC Tech will at foremost be a place and office start up, using one studio room in the proprietors place and functioning clients in the local Karachi and Hyderabad country. In the 3rd month of our program, we will travel into a leased office infinite and engage 2nd technician. As gross revenues addition, we will engage extra forces.MarketPersonal computer Tech has decided to concentrate on little concern market, as these clients do n't hold lasting IT Technicians but they have strongly IT technician demands. Personal computer Tech will offer inexpensive rates, on call services for these clients. We can besides offer Contract base understandings that create extra monthly fiscal income. For residential clients we offer a really sensible and friendly base 24/7 service Pc Tech mark market will concentrate on Karachi and Hyderabad and environ ing countries. Market consequence demoing that in Karachi and Hyderabad there is a batch of PC fix concern for Personal computer Tech.Support and FinancialsTo get down the Personal computer Tech the proprietor is financially support hard currency and aids. We are besides looking for bank loan, and we will refund within four old ages. Our gross revenues forecast based on market research within local countries. projected gross revenues in one twelvemonth steadily turn through twelvemonth three. To accomplish these undertakings, we will urgently publicize to work Personal computer Tech rivals weak points. With good disbursal control, we will look into a modest, comfy, 1st twelvemonth net income, even engaging new technicians.AimsTo supply good quality services in a sensible monetary value.To publicize Personal computer Tech promotion often so that Personal computer Tech is common name.Maintain gross revenues growing from start-up through twelvemonth three.Customer satisfactions at leas t 60 % so clients will gives us more concern.Personal computer Tech MissionPersonal computer Tech ends to put criterion for on call or on site Personal computer support through fast, remotely service response and on site as good. Our clients will ever have 24/7 service at a really sensible monetary value. Our clients will have highest quality client support service. We will gives developing to our employees, great environment to work, pay plus benefits and fillip and auto, In return our employees gives good judgement to work out clients ‘ jobs.Keies to successMaking trade name individuality and acknowledgment trade name through selling.On call response with great client service.Quality: No hole no feesDeveloping client relationship-retainers.Personal computer Tech Company SummaryPersonal computer Tech is located in Karachi owned by M.Amir. With little bank loan 3 old ages. Personal computer Tech will turn their service in 1st twelvemonth from 1 adult male, place and office bas ed, computing machine fix store to profitable 2 individual concern in rent location. We will supply necessary design to fastest and expeditiously react to clients computing machine demands, fastest velocity, and sensible rate of proficient support.ServicessPersonal computer Tech will supply computing machine mending, proficient support, making computing machine webs substructure, virus remotion, Server design. As Personal computer Tech clients demands grow, So PC Tech will offer web designing, package development, to our clients.Day foremost, Personal computer Tech on site, on call, distant entree and consulting service. So that we can salvage our clients or client clip to drop their Personal computer ‘s in Personal computer Tech workshop.Personal computer Tech will offer web care contracts so clients can cover proficient support and fix, instead than to be after unexpected informations loss or system clangs and jobs.Personal computer Tech offer limited free package installing so our clients will gives us more concern, we will supply backup recovery, salvaging informations with multiple runing systems like Windowss, Mac, Linux, Unix.PC Tech focal point on hardware and networking support.Market AnalysisPersonal computer Tech will supply web support in both confer withing and proficient issues to little concern and place based users. Since Personal computer Tech is presently a one adult male operation, the first three months growing of Personal computer Tech will be limited by the proprietor ‘s capacity to finish work. These first three months are critical for Personal computer Tech set uping credibleness and repute acquiring the occupation done every bit rapidly as possible. Personal computer Tech focus frontward on presenting first-class client support and proficient support utilizing good word of oral cavity for this initial period to web with other possible clients. Personal market research indicates by the proprietor an attractive market niche f or Personal computer Tech services, of which PC Tech will take full advantage. Customers need aid with everything from installing of package and hardware aid, networking, web cabling, reassigning files from old Personal computer to new Personal computer. Small concern proprietor s need dependable and rapidly assist with their computing machine demands, since every hr down may intend an hr or lost of gross specially for those concern who utilizing web site for e-commerce dealing and E-business.Market CleavageWe have broken our possible market down into two groups, based on client demands, Home-based users and little Business user.Home-Based UserHome-Based users use sophisticated applications by and large have adequate tech cognition, from engineering experience at work to make their ain computing machine mending and hardware upgrading. They change their hardware and will include computing machine itself, proctors, keyboards, mouse, pressman and scanner. Home-based group somewhat turn ing faster than the overall population growing in our country, due to the increasing on-demand computing machines old and retire people and immature households, approximately 8 % a twelvemonth.Small Business UsersSmall concern users will gives good concern to PC Tech, with 4 or more Personal computer ‘s or a web which they use for commercial or concern intents at least 40 % of clip. Small concern clients use include minor use like Windowss or package updating, website updating, book maintaining, stock list trailing, POS systems, informations entry, on-line product/service bringing and merchandise development, in writing designing and composing letters or transcripts for imperativeness release. The more intensive computing machine use for little concern, more critical it is to them their tech work good and faithfully, and that quality fixs and support Personal computer Tech are available in a crisis. Their Personal computer ‘s require will include same points which home u sers need, plus their waiter backups, system backup, storage their informations, and wifi networking. Small concern we are aiming is turning about 4 % a twelvemonth.Target Market StrategyAlthough there are more home-based clients, we believe the bulk of Personal computer Tech gross to come from little concern clients, they need our pressing service attending, and they are puting in tech as portion of their little concern scheme. Our selling focal point frontward on little concern proprietors. Most of the little concern clients do non hold full clip IT Technician, but they need full clip IT Support. Home based computing machine utilizing multiple users, they use it for multiple intents. Personal computer Tech home-based users need assist pull offing puting to incorporate the different demands family members they need proficient aid. Personal computer Tech are besides selling peace of head we provide on-call service in friendly environment, efficient aid merely a phone call off. As comparison more companies transfer their call to automatize call Centre ‘s or touch -tone bill of fare, Simple reassurance of hearing another voice on the phone within a few rings is unmeasurable. Within a few hours person will assist you and work out their job. In computing machine Technology both in package and hardware side continue to turn let go of new Personal computer constituents at dismaying rates. For Personal computer Tech this means occupation security good into the hereafter.Business Analysis ServiceSecondary research market shows IT service clients tend to be really sincere to suppliers that do good work and gives their clients 100 % satisfaction of their demands.An analysis of Personal computer Tech chief rivals shows no overpowering strengths that would be important protocol to entry into market, as local rivals h ave major failing. Computer fix and care industry is fragmented, with some big, national participants and 100s of little, local shops. Most Personal computer ‘s are fix in shop, near the client, computing machine fix parts come from well-known companies and distributors, hold having parts can decelerate down fix procedure. Large companies solved this job by maintaining huge sums of parts in stock at all times, while local stores offer clients of personal interaction and trust that may repair the portion for some hold. Personal computer Tech will set up a relationship with a local distributer to make special-ordering, although this capableness is more expensive than normal channels. It will enable rapidly set up a good repute as efficient and responsive to their client demands. For little concern users We will publicize purchase this client trueness with great word of oral cavity selling and steady growing.Scheme and execution SummaryPersonal computer Tech Strategy and executio n on three key pointsA value proposition of timely and practical solutions, at cheapest rate as comparison to market rates, with 100 % warrant.Exploiting Personal computer Tech rivals failing,

Confucianism and Legalism

Confucianism and Legalism Confucianism and Legalism were two philosophies developed by scholars as solutions to a period of disorder in China. Confucianism and Legalism are similar in that both originated during the Chinese Classical Period; however, they are different in government because Confucianism focuses on having an orderly, respectful, and successful ruler, while Legalism focuses on having an forceful and omnipotent ruler.In addition, education is extremely important in Confucianism, as opposed to the Legalist belief that people should never gain much knowledge. Both Confucianism and Legalism were developed in China during the Classical Period as solutions to bring back peace and harmony to the area. After the decline of the Zhou dynasty, there was a breakdown of social order (The Period of Warring States), so Chinese scholars and philosophers looked for ways to bring back a state of order and peace.Two different schools of thought, Confucianism and Legalism, developed as wa ys to move China out of chaos and help it return to stability. Another philosophy, Daoism, is similar to Confucianism and Legalism because it was also developed during the Classical Period in China as a solution to the disorder. The styles of governing found in Confucianism and Legalism differ greatly because Confucian government focuses on leading by example, while Legalist government focuses on having an all-powerful government in order to make sure people do not disrupt society for their own gain.Confucians believe that a ruler must be orderly, respectful, and successful in order for his subjects to obey him. This idea is due to their belief in The Five Relationships, one of which is between ruler and subject stating that subjects shall obey their ruler as long as the ruler respects the subjects. Legalist and Confucian beliefs are different on this matter because Legalists think that a ruler can do whatever he wishes regardless of his subjects, while Confucians value respect and devotion throughout society.They believe that there must be an all-powerful and forceful government in place to control society. The reason they think this is because they believe that humans are selfish in nature and that their desires bring about chaos and disorder in society. The views of Confucianism and Legalism on education are very different in that education is very important in Confucianism, while Legalism tries to restrict learning as much as possible. Confucianism deems education as the most important thing a person can have.This is because the Confucian social order – differing from the Legalist social order that focused mainly on ancestry – was not specifically based on birth, but on education as well; the more educated a person was the higher their status could be. However, Legalists believed that anyone or anything that opposed the emperor must be controlled by censorship. Those who opposed the emperor were punished or killed, and works that expressed op position were destroyed. The reason for these actions is that the powerful emperor did not want his reputation to be impaired by other’s â€Å"selfish acts.Confucianism and Legalism are both similar in that they developed at the same time in China; however, they are different in that in order to control society Confucians believe in governing by example, while Legalists believe in governing by force and power. Additionally, Confucianism and Legalism differ in that Confucianism values education to the highest degree, whereas Legalism tries to limit the knowledge of society. Both of these Classical Period philosophies were built up in order to pose as solutions to a period of disorder in China.

Distracted Driving Essay

Distracted Driving is a selfish and very dangerous way to drive. Over 3,000 people each year are killed due to either driving distracted or being hit by someone who is distracted. There are many types of distracted driving and all are equally as dangerous. Examples of distracted driving include texting, eating, talking to a passenger, adjusting a radio or iPod, and anything involving your phone or a gps. Any kind of distracted driving is a bad idea and can end in serious injuries or fatalities. Distracted driving has numerous definitions. Whether it be eating, drowsy driving, using your phone, talking to a friend, or being distracted by something on the side of the road, they are all very dangerous and can end with someone using their life. Many people believe that they may be a good driver even when being distracted by other things but it is usually not the case. Even if you get away with driving distracted, it wont always be that way, and you never know when your luck will run out. As good as you may be at multitasking while driving it is never a good idea. If the thing is that important you should pull to the side of the road or wait until you get to your destination to do what you need to do. Texting and driving is one of the highest causes of crashes and fatalities. One of the groups that is most at risk is teens 16-20. This age group is not only new and inexperienced drivers but they are also very distracted by cell phones and music. When you are texting and driving the minimal amount of time that your attention is taken by your phone is 5 seconds. This not only puts you in danger but it also puts others on the road in a lot of danger as well. As important as receiving or sending a text may be, it can wait long enough to keep your life, and others, safe. If it is too tempting for you to use your phone or iPod while you are driving there are many ways you can combat this urge. All you need to do is throw your phone in the backseat or in the glove compartment and your urge is gone. You can also put your phone on silent or turn it off if the vibration or sounds of receiving texts distracts you. Any of these quick alternatives is a great idea to save your life as well as others on the road with you. Talking to a passenger or on your phone is a dangerous distraction as well. If you are on your phone, you may think that your attention is on the road but your attention is drawn away and focused on your call. Even if you use a hands-free device you still have a large amount of your attention drawn away. Talking to a  passenger in your car can be more dangerous because they are able to distract you and interact with you more. This can be helpful if they are alerting you of obstacles but if they are being distractive it can be a large distraction. If they are posing a bigger distraction than a help then you should let them know that you are distracting you from the road. Although it may offend or anger them, it can pay off in the long run. Another minor way of being of distracted is things in your eyesight. Someone running alongside the road, something happening ahead of you or to the side, and anything that will take your attention is a distraction. Things like this can seem minor but they can impair your attention. Although you don’t want to tune these things out of your attention, because they can cause accidents, you need to not only be aware of these things but not let them distract you to a point where you cant notice what is going on around you. There are 3 main types of distracted driving; cognitive, visual and manual. Cognitive distractions are when you mind isn’t focused on driving. These can include talking to someone in your car and just daydreaming. Even listening to music can take your mind off driving and distract you. This may seem like a minor distraction but it can be very large. A visual distraction is anything that involves the driver taking his or her eyes off the road. This is common in all age groups; adults will check their kid’s seatbelts and almost everyone will use a GPS, iPod, phone or dvd player. All of these things that involve you taking your eyes off the road are considered a visual distraction. The last type of distraction is manual. A manual distraction is when you take one or both hands off the wheel for any reason at anytime while driving. A manual distraction can include eating or drinking, adjusting a GPS or iPod, reaching for something, or even adjusting your seat. One of the reasons that texting ids one of the most dangerous thing you can do while driving is because it involves all 3 types of distracted driving. There are many ways that you can avoid using any of these types of distracted driving. The first way to avoid these three is to turn off your phone, even if you are expecting an important call. Another tip is to get a hands-free device if you really need to. This is not a great idea to use because it is just as dangerous as using the phone itself. Also, if you are driving with kids and/or pets make sure they  are strapped in and secured so that they don’t pose a distraction while they are driving. If you need to eat or drink, finish it before you start driving, or wait until after. The last is, if you use a gps, program it before you start driving. All of these reasons are great examples to stop driving distracted. Driving while distracted is elfish and cost you, and others their lives. It’s a simple choice, just wait to start or finish your task. http://www.distraction.gov/content/get-the-facts/facts-and-statistics.html http://www.textinganddrivingsafety.com/texting-and-driving-stats/ http://www.esurance.com/safety/3-types-of-distracted-driving

Detente – Was it successful?

However, the term D ©tenet simply means a loosening of tensions, which did happen ND therefore is it correct to say that it failed? D ©tenet certainly backed away from more incidents like the Cuban Missile Crisis happening once again, and cooperation increased between the powers significantly, therefore to a fairly large extent I don't agree that D ©tenet was a failure. The policy was often viewed as ‘soft' and it was criticized by many Americans because the aggressive Soviet Expansionism continued.On the other hand though, expansionism doesn't signify any failure, because D ©tenet was not a tool to stop communism from spreading like containment was, but a policy to reduce tensions, or this reason Soviet Expansion can't be seen as a factor for the failure' of D ©tenet to any extent. It was also viewed as a failure because not all of the policies worked, for instance the Helsinki Agreement of 1975 was an agreement based around human rights, it was completely dismissed by the USSR, who viewed it as a ‘scrap of paper and as a country they continued to suppress people.Moreover, other agreements had faults too, such as SALT 1 which failed to put caps on new advances of weapons and which only lasted for five years. To some extent these policies can be seen to have failed, yet despite these downfalls, as a whole we cannot view D ©tenet as a failure because there were positives to the policies, such as Increased communication which In turn reduced tensions – the alma of D ©tenet. Other people viewed D ©tenet as a failure because The Cold War continued afterwards; they wanted D ©tenet to end the war completely.Following the period of D ©tenet, the appointment of Ronald Reagan as president of America led to a period of the ‘Neo-cons', a group of people that hated communism and wanted to eliminate t. For this reason, the Cold War fired up again, and some people believe that because of this, the policy of D ©tenet was a failur e; however to a large extent this is untrue, because D ©tenet was never a promise to end the Cold War, and both the Americans and the Soviets were aware that it was not the end. D ©tenet was a promise to reduce tensions, which It did successfully to a great extent.On the other hand, when reviewing D ©tenet overall In relation to Its aim, It was incredibly successful. The policy of D ©tenet aimed to reduce tensions between the Missile Crisis, which put into perspective how easily the countries could destroy each other; MAD, mutually assured destruction was the name given to this realization. In terms of mutually assured destruction, d ©tenet was a positive thing; it increased communications for example through the use of the hotlist set up and these steps avoided further crisis.For this reason, D ©tenet was to no extent a failure. In addition, D ©tenet had other successes for both America and The Soviet Union. America were able to use D ©tenet as a tool to get out of Vietnam, which was positive n terms of its international relationships. Moreover, D ©tenet stopped the Soviet Union from feeling isolated by the relationship built up by China and America, which was positive because this in turn reduced tensions and increased communications – the overall aim.Finally, D ©tenet improved the economic situation in both America and The USSR after the arms race had taken it's toll, this was done by an increase in trade and technology across the iron curtain. All these factors were positive and the loosened tensions between the superpowers, therefore D ©tenet was without a doubt success in achieving its aim. In conclusion, it's obvious that D ©tenet did have many downfalls and for this reason many people instantly conclude that it was a failure.On the other hand, to a large extent D ©tenet achieved its purpose because many policies reduced the tension that was present. D ©tenet should not be seen to have failed due to the fact that the C old War continued, because that was not the intention of the policy. Overall, it's evident that d ©tenet was only a failure to a marginal extent because of the downfall of some of the agreements, yet to a significant extent, D ©tenet was a success.